In a healthy human gastric mucosa possesses significant potential regeneration. Acute lesions induced by dietary, infectious, toxic and medication factors are just a few days or weeks with proper dietary regimen and eliminating their causes. Cardiac, renal, respiratory failure, as in liver failure, there are persistent, difficult to treat chronic gastritis and gastroduodenitis. Between the condition of the gastrointestinal tract and other systems and organs are complex interrelationships. Heart failure, and often in chronic liver disease, primary importance is impaired trophic gastric mucosa. In renal and respiratory failure compensatory increases the secretion of hydrochloric acid, kidney and liver failure - the value has evolved hypergastrinemia.