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Hydroxychloroquine prescribed for: Hydroxychloroquine is used for the treatment of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It also is used for treating rheumatoid arthritis, and chronic discoid and systemic lupus erythematosus when other therapies have failed. It may prevent relapse and relieve skin inflammation, hair loss, mouth sores, fatigue, and joint pain caused by systemic lupus erythematosus.