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Estradiol prescribed for: Estradiol is prescribed for symptomatic treatment of the usual symptoms associated with menopause (hot flashes, vaginal dryness, etc.), prevention of bone fractures associated with osteoporosis, reduction of the risk of heart attacks and strokes, and dysfunctional (excessive and painful) uterine bleeding. The vaginal cream is prescribed for vaginal or vulvar atrophy associated with menopause.