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Isosorbide mononitrate prescribed for: This medication is a nitrate drug. It is used to prevent chest pain (angina) and reduce strain on the heart in patients with heart disease (coronary artery disease). Isosorbide mononitrate relaxes and widens blood vessels so blood can flow more easily. This medication will not relieve chest pain once it occurs. It is also not intended to be taken just before certain activities (e.g., exercise, sexual intercourse) to prevent chest pain. Other medications may be needed. Consult your doctor for details. This medication may also be used in addition to other drugs to improve the symptoms of congestive heart failure (e.g., trouble breathing).