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Lisinopril-hctz prescribed for: This drug is used to treat high blood pressure (hypertension). This medication is a combination of two drugs (an ACE inhibitor and a thiazide "water pill"/diuretic). Lisinopril works by relaxing blood vessels, causing them to widen. The thiazide diuretic increases the amount of urine you make, therefore decreasing excess water and salt in your body. High blood pressure reduction helps prevent strokes, heart attacks, and kidney problems.