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Rivaroxaban prescribed for: Rivaroxaban is a prescription medicine used to: reduce the risk of stroke and blood clots in patients with atrial fibrillation not due to a heart valve problem, treat and reduce the risk of deep vein thrombosis (DVT, blood clots in the veins of the legs) and pulmonary embolism (PE, blood clots in the lungs) and reduce the risk of blood clots in the legs and lungs of patients who have just had hip or knee replacement surgery.